Alex Ferguson is likely to make changes at Wigan as they have had one less day of rest than the hosts.
Phil Jones could start in place of Rafael at right-back, While Nani is nearing full fitness and could feature.
Javier Hernandez may get his chance to start alongside Rooney again after Welbeck missed a number of chances against QPR.
Wigan will go into this game feeling aggrieved having been on the wrong side of two poor decisions which led to defeat at Chelsea.
The home side will hope that United will lose focus after all but retaining the title following City's loss, though Alex Ferguson is not one to let that happen and will want to pick up maximum points for the rest of the season.
Martinez can take plenty of heart from the performance at Stamford Bridge, and from a number of encouraging performances recently, but United should have too much and be too strong at the back.
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