Lisandro Lopez is likely to still be missing so Bafe Gomis will lead the line on his own once again, though he is without a goal in 3 matches and will have a tough task changing that against an organised Mourinho side.
The main news for Lyon is that they will be without Michel Bastos due to a hamstring injury.
Jose Mourinho has a few injury worries in his squad, namely Albiol, Carvalho and Sahin, who will all miss out.
As always, the Real manager will have selection dilemmas purely down to the embarrassment of riches in his ranks. Kaka is a doubt so it is likely Angel di Maria will start, whilst the in-form Gonzalo Higuain may lose out up front to Karim Benzema, who could face his old club.
Alvaro Arbeloa faces a race to be fit, but Raphael Varane could come in for him, with Sergio Ramos moving to right-back.
Real have won all three of their Group D matches, scoring 8 goals in the process and conceding none. A win in France would put them through to the next round with 2 games to spare, while if they win and Ajax fail to do so, they will be guaranteed top spot.
A fortnight ago, Real ran out 4-0 winners over Lyon and will be confident given their domestic form as well. Lyon have won 3 and lost 3 of their last 6 matches - all of their wins have come against supposed 'lesser' opposition while they have lost against Lille, Real and PSG, who all pose a bigger threat. A Real win looks by far and away the most likely result.
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