Jose Mourinho should rest all his big guns with the Liga game against Barcelona on the horizon.
Plenty of his first team squad will not travel to Holland, while players such a Sahin, Callejon and Kaka will get a chance to stake their claim for a first team berth, and also build up their match fitness.
Alvaro Arbeloa is another player who will enjoy a run out.
Ajax have not reached the second round of the Champions League since 2005, and stand their best chance in the intervening 7 years of achieving just that. A (somewhat unlikely) draw would be sufficient for them to qualify, though they can also qualify if the lose, but Lyon fail to overturn the 7 goal deficit they currently trail by.
Real will rest the vast majority of their first team, as they have already won the group, and face Barcelona in the first Liga 'Clasico' of the season this weekend. That match represents one of the most important of the season for both Spanish giants, and Mourinho will want to have his in-form team fresh and ready for that game.
With Ajax missing a large number of their squad through injury and Real set to rest their first XI, it is difficult to know how this match will pan out. Real do, however, have so much attacking flair that even their second string should be strong enough to nick this one, though Ajax should keep it to a minimum and thereby qualify.
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