With the tie all but won in the first leg, Sir Alex Ferguson might rotate his lineup to give some game time to those of his squad who need it most. However, squad rotation played a big part in United's elimination from the Champions League so he will be careful not to make the same mistake again.
Wayne Rooney has been ruled out with a throat infection, so Dimitar Berbatov could start along with the likes of Tom Cleverley and Ashley young, who both continue their recovery from injury.
Having had the weekend off, plenty of United's squad should be fresh for this game, but Ferguson will no doubt have half an eye on this weekend's trip to Norwich.
Despite losing to Manchester United, there are signs that Ajax have put their poor form at the beginning of 2012 behind them. After Saturday's 4-1 win over NEC Nijmegen, the reigning Dutch champions have now won back to back games for the first time since before the winter break.
Ajax have plenty of absentees, with Van der Wiel, Enoh, Boerrigter, Janssen, Oojer, Signthorsson and Boilesen all injured.
The onus will be on the likes of de Jong, Eriksen and Sulejmani to create scoring opportunities, with Ajax in need of at least two goals to stand any chance of staying in the competition.
Ajax have no choice but to come to Old Trafford with the intention of attacking and running the risk of conceding a few goals if they leave themselves open.
The likes of Ashley Young and Danny Welbeck could well exploit a team that opens up, breaking at pace. Ajax will do well to score themselves, regardless of the threat on the counter attack that Manchester United pose.
United are experienced at a European level and will have learnt from their mistake in underestimating opposition in their Champions League campaign this season. They should be well prepared enough to see off their Dutch counterparts here, and move safely into the next round.
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