The likes of Marc-Andre ter Stegen and Julian Draxler, who made their debuts in a shock friendly defeat to Switzerland last time out, have both been cut from the squad along with Sven Bender and Cacau.
Bastian Schweinsteiger is a doubt with a calf injury and unlikely to be risked as Low does some more experimenting before the tournament begins.
The rest of the Bayern players who were rested last time out due to their Champions League exertions are likely to return, while Marco Reus could start having scored his first international goal from the bench against the Swiss.
Itay Shechter and Yossi Benayoun are the star men for Israel, with the latter supporting the Kaiserslautern striker in the free role.
Palermo midfielder Eran Zahavi also has a key role, while former Chelsea centre-back Tal Ben Haim will be charged with marking Mario Gomez.
Germany need to bounce back after a disappointing defeat fielding an experimental line-up against Switzerland. The team should be more familiar with the Bayern stars returning to the side, which should sure the defence up after conceding 5 last time out.
Israel are unlikely to pose as much of a threat as a decent young Swiss outfit and are more likely to play a defensive game and try to limit the Germans opportunities. Doing so against a team with the likes of Ozil, Muller, Gotze and Reus all hoping to play will be an incredibly tough task.
Expect Low's side to return to winning ways in emphatic fashion to boost their confidence before the Euros begin.
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