The Tottenham trio of Walker, Lennon and Defoe all have hamstring injuries, with Ashley Cole also sidelined and Rooney and Shelvey forced to withdraw from the squad.
In turn there have been debut call-ups for youngsters Jenkinson and Zaha, along with Everton's Leon Osman, who could receive his first England cap at the age of 31.
Danny Welbeck is likely to start up front, with Sturridge the only other real striking option, while the likes of Shawcross and Huddlestone will hope for a chance to feature in a new look squad containing the fit again Jack Wilshere.
Captain Steven Gerrard will earn his 100th cap, becoming only the 6th ever England player to do so.
These two sides have met 6 times since the turn of the century, with their encounters in that time never decided by more than a single goal, most recently in a 3-2 win for England at Euro 2012.
England are yet to lose since the summer tournament, though draws against the likes of Ukraine and Poland mean that their qualification for the World Cup is far from assured, while Sweden come into the game on a high having come from 4-0 down in Germany to draw 4-4.
Hodgson's side is a very young one, while Hamren hasn't really experimented with recent squads and has a far more familiar selection to choose from. Expect another close encounter come Wednesday.
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