Karim Aït Fana is set to miss out with a knee injury, while Joris Marveaux has a thigh problem.
Goalkepper Geoffrey Jourden is a doubt with a rib injury, and Garry Bocaly is expected to miss out due to a hip complaint.
Jamel Saihi returns from suspension but Cyril Jeunechamp is banned indefinitely until the league's disciplinary panel come to a decision regarding an altercation involving the defender and a member of the media following the draw with Valenciennes.
Lyon welcome Montpellier to the Stade de Gerland after propelling themselves to the top of the Ligue 1 table.
Les Gones stormed to the top of the division in midweek with an emphatic 4-1 win over fellow title chasers Marseille, which was inspired by the form of striker Bafetimbi Gomis, who netted an impressive hat-rick to take his tally for the season to nine goals.
Montpellier also enjoyed a good week in domestic competition as they backed up their win over Bordeaux last weekend with a 3-2 triumph against Nice in the Coupe de la Ligue.
Remy Cabella has been the star man for La Palliade in recent weeks, and he will be expected to provide the creativity against a Lyon team that has lost just twice this term.
This should a tightly fought contest with plenty of goals, however with Lyon in confident form following their impressive victory in Provence, they should be able to earn another three points and reaffirm their title credentials.
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