Lille will be without Tulio De Melo due to a groin injury, while Ryan Mendes and Salomon Kalou are both away at the African Cup of Nations.
Nancy will try and start life after Jean Fernandez with a win when they take on Nancy at the Stade Marcel Picot on Saturday.
Les Chardons endured a nightmare first half of the season and sit at the bottom of Ligue 1, eight points adrift of safety and facing an uphill challenge if they are to retain their top flight status.
They face a Lille outfit that looks to be beginning to find top gear, the 2011 champions easily dispatched of Montpellier in the final game before the winter break, Nolan Roux scoring twice in a 4-1 win.
The former Brest striker will once again be the focal point of the visitors' attack, and although Les Dogues have recently lost Mathieu Debuchy - one of the stars of their title-winning campaign - to English side Newcastle United, Rudi Garcia's men should be able to take all three points if Roux can continue his fine form.
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