Evian are set to be without a number of first team regulars.
Brice Dja Djede is out through injury, while Bertrand Laquait, Johann Durand and Aldo Angoula are all suspended.
Cedric Mongongu, Jonathan Mensah, Mohammed Rabiu, Djakaridja Kone and Saber Khlifa are all on African Cup of Nations duty and will be absent for the foreseeable future.
Lyon will look to cement their place at the top of Ligue 1 against struggling Evian at the Stade de Gerland.
Les Gones moved to the summit of the division with a 2-1 win over Troyes, with Maxime Gonalons and Samuel Umtiti both netting in a tight contest. Evian continued their slide however as they fell to a 2-0 home defeat to Brest.
Sidney Govou is likely to make an appearance against his former club for Les Roses, and he will hope to provide some creativity for a side that has been inconsistent in front of goal this term.
Still Pascal Dupraz's men will go into the game as underdogs, and anything other than a comfortable win for the hosts will be a huge surprise.
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