Toulouse will be without Adrien Regattin and Pavle Ninkov, who have knee injuries, while Jonathan Zebina will also miss out with a thigh problem.
Aymen Abdennour is taking part in the African Cup of Nations with Tunisia.
Reims take on Toulouse hoping to earn their first win since October against a Toulouse side that ended a slump in form with a 2-1 win over Nancy.
Hubert Fournier's strugglers have not won since their 3-1 win over Nice and now sit in the relegation zone after taking just five points in the last three months.
They face a Toulouse side that has fallen away from the top four after initially making an excellent start to the season and will now have to finish the term without Moussa Sissoko, who looks set to join Newcastle United.
Still La Tefece possess a team plentiful in quality, and although Reims have added some depth to their forward line by signing striker Nicolas De Preville from Istres, it is doubtful that it will be enough to guide them to a much needed win.
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