Barcelona meanwhile also got out of a jam at the weekend as two late goals from Lionel Messi secured a 2-1 win over Osasuna.
Tito Vilanova had rested Javier Mascherano, Xavi and Pedro from the start in Pamplona and all are expected to return for the clash at the Bernabeu.
Carles Puyol fractured his cheekbone on Sunday and is a major doubt.
One final change from the weekend could see Adriano come in for Jordi Alba as the Brazilian started Barca's 3-2 win in the first-leg last week and in the main kept both Jose Maria Callejon and Angel di Maria quiet.
Real have looked extremely rusty in their three competitive games to date and had a Victor Valdes error to thank for keeping them in the tie as he gifted a goal to Di Maria late on last week.
Pepe's return will though certainly strengthen the Real rearguard and a big performance will be expected of the champions given Mourinho's uncharacteristic public criticism of his players after the Getafe defeat.
However, the problem as ever for Real will probably be Messi. The Argentine has already scored five goals in three games so far this season and has a habit of scoring important goals at the Bernabeu.
Barca's first-leg advantage should be enough to see them claim the first silverware of the season, but expect a high-scoring affair as clashes between these two have consistently been over the past year.
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