United could have an injury crisis in defence, with Smalling definitely out, Evans a serious doubt, Jones recovering from a back problem and Rio Ferdinand ruled out for 3 to 4 weeks over the weekend.
If Evans does not recover in time, Michael Carrick may have to play at the back, with Scholes, Anderson or Giggs likely to play in central midfield.
With Rafael having missed pre-season with the club due to his Olympic commitments, Antonio Valencia could be asked to fill in on the right, with captain Vidic returning alongside Ferdinand.
The big debate will be whether Robin van Persie starts after his shock move from Arsenal. Despite Ferguson claiming that he could well make his debut he won't have played with the side prior to Monday's game so should sit on the bench.
There should, however, be a debut for Shinji Kagawa in behind Wayne Rooney.
Everton have only beaten United once in their last 14 Premier League meetings but have been involved in some memorable encounters with Ferguson's side, twice coming back from two goals behind in the final 10 minutes to pull level in the previous two seasons.
Moyes has had a fairly quiet summer, as expected, but did get his man with the permanent return of Pienaar, while Naismith has settled in well. United's signing of van Persie is perhaps the biggest deal in terms of shock value this summer, though Shinji Kagawa's arrival should not be underestimated and they will be a real force to be reckoned with in attack.
An away day at Everton is not an easy start for the Red Devils, who many would agree are still short in central midfield, but eye-catching new signings coupled with the return of Nemanja Vidic should see them hold off the Toffees this time around.
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