Sergio Aguero suffered a knee injury against Southampton that is set to keep him out for a number of weeks, though the exact duration of his absence is still unclear. Edin Dzeko could replace the Argentinian up front, while Mario Balotelli is another option.
With Gareth Barry also injured and rumours amassing that Nigel de Jong is on his way out the door, Jack Rodwell could play in central midfield again alongside Yaya Toure.
It seemed against Southampton that Roberto Mancini had decided against using the 3 man defence he tried out in pre-season, so it will be interesting to see which formation he opts for at Anfield.
Possibly the standout game of the weekend is at Anfield this week, with champions Manchester City paying Brendan Rodgers' Liverpool a visit. The home side will need to be much improved from their abject showing at West Brom last week. They kept the ball well, in true 'Brendan Rodgers style' but they lacked a cutting edge up front, and failed to break through the West Brom defence.
Manchester City showed why they are champions, coming back from 2-1 down with 20 minutes to go to take all three points despite a very good performance from Southampton. They will need the likes of David Silva to improve, though, particularly with Aguero now out for a few weeks at the very least.
The home crowd will be fully behind their team and that will certainly help them along. They will keep the ball more than most teams manage against City, but the onus may be on Luis Suarez to inspire his side. City, meanwhile, look far from their best defensively, but as strong as ever going forwards, so once again, they should see goals at both ends.
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