Rafa Benitez takes charge of his first game in charge as 'interim manager' at Chelsea, and he will likely reinstate Fernando Torres as the lone striker after he was dropped to the bench for the Juventus game in midweek. Benitez got the best of Torres at Liverpool and will be expected to do so again at Chelsea.
Daniel Sturridge is a doubt, while John Terry and Frank Lampard are still out injured.
As there has been a change in managerial staff at Stamford Bridge, there could be some changes made to the usual starting XI.
Vincent Kompany was seen leaving the Etihad on crutches after the midweek draw with Real Madrid in the Champions League, and it is not yet clear how bad the injury he sustained was.
Gael Clichy missed that mach with a foot injury and may not return in time to play at Stamford Bridge.
Robert Mancini may opt to play Yaya Toure further forward and an extra defensive midfielder against Chelsea's vast attacking talent in midfield.
The game of the weekend rounds off proceedings, with Rafa Benitez facing champions Manchester City in his first game as manager of Chelsea. Many Chelsea fans think badly of the Spaniard because of the rivalry between Chelsea and Liverpool during the years he was at the Reds, so he will be looking to make a quick impression on them.
City remain the only unbeaten side in the Premier League but are still only four points ahead of Chelsea, so a win for the London club would put them in touching distance of their title rivals.
City's away record this season has seen them draw three out of five games, and that could be the likely result. Chelsea have a very good home record against City, but City have improved vastly in recent years so that record counts for little.
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