Mikel Arteta is sidelined with a calf injury so the return to fitness of Abou Diaby has proven timely. Wenger may be cautious about playing him three times in a week though, so Coquelin is on standby.
Elsewhere Aaron Ramsey may have earned a rare start given the poor form of Alex Oxlade-Chamberlain lately.
Theo Walcott should move back to the central striker role after Olivier Giroud failed to impress in cup action against Swansea on Wednesday.
There has not been a draw between Chelsea and Arsenal in the league at Stamford Bridge since 2006, so despite the fact that it is likely to be a tight game, one side usually comes out on top, with just 1 draw in their last 11 league meetings in total.
Rafa Benitez would perhaps have preferred this to be an away game having won 4 on the trot on the road compared to just 1 victory in 5 home league games in charge of the Blues.
Arsene Wenger will know that defeat here may well rule them out of the running for an automatic Champions League qualification spot as they would fall 11 points behind Chelsea in third, so the visitors can't afford to sit back in what should be an entertaining game.
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