England have no injury concerns so could stick with an unchanged XI despite a disappointing performance against Ukraine.
Wayne Rooney will keep his place up front, while Welbeck and Carroll will continue to fight to be his strike partner.
There have been many calls for either Walcott or Oxlade-Chamberlain to get the nod over Milner, though Hodgson prefers a flat 4-4-2 and the City-man's defensive qualities are likely to see him start to combat Italy's attacking full-backs.
Prandelli received a big blow with the news that centre-back Giorgio Chiellini will miss the quarter-final through injury.
The coach could revert to a flat back three used in the first two games, with De Rossi dropping into defence once again, but is more likely to stick to a 4-man backline, keeping Abate and Balzaretti out wide.
Though they lined-up in a 4-3-1-2 formation last time out, the reality of the player positions is more of a 4-1-3-2, with Pirlo given the creative licence in behind a likely partnership of Cassano and Balotelli.
Despite a thoroughly underwhelming display in Donetsk, England qualified top of Group D and avoided a clash with Spain in the process. Although the nation will be optimistic having done so, the Italians will rightly be favourites in this game.
Prandelli's side will dominate the tempo, with everything going through Pirlo, as ever, while England will soak up the pressure and utilize set-pieces and counter-attacks.
An interesting clash could see teammates Balotelli and Lescott come head-to-head and if England's defence can remain resolute there is no doubting that this will be a tight game, which could go all the way to extra time and even the dreaded penalty shoot-out
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