Vicente Del Bosque has a settled starting XI, with the only debate over whether to begin the game with a recognised striker in Fernando Torres or a fluid front three, with Fabregas leading the line.
The former is perhaps the favoured option, though Llorente and Negredo are also waiting in the wings should he slip up.
Jesus Navas may have played himself into contention with a winning goal from the bench against Croatia, though any changes outside of the central striker role seem very unlikely, with a fully fit squad to choose from.
The only absentee for France is set to be Philippe Mexes, whose second yellow card of the tournament against Sweden sees him suspended for this game.
With no other real alternatives, Arsenal's Laurent Koscielny will therefore have the chance to prove that he is worthy of a place in the XI should Blanc's side progress.
Hatem Ben Arfa didn't really take his chance to impress last time out, so either Malouda or Menez could return, though Blanc could also go like-for-like against the Spaniard's with a defensive trio in midfield and three up front.
Spain's route to the quarter-finals was not as plain-sailing as expected, with Croatia within one-goal of knocking the reigning champions out in the final group game.
France looked impressive despite only managing a draw with England before a comfortable win over Ukraine. However, a lacklustre display and defeat to Sweden has cast doubts over their credentials to go all the way.
Blanc's side do not have a defensive outlook and their best players undoubtedly play higher up the pitch. Therefore they are unlikely to merely try and contain Spain, so this should lead to chances at either end in what should be an entertaining game.
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