Dennis Aogo is out for two weeks and will be replaced by Zhi Gin Lam.
New signings Milan Badelj and Petr Jiracek will start in central midfield again.
Former Hamburg captain Rafael van der Vaart will make his season debut, after returning to the club this summer.
Artjoms Rudnevs will get his chance to start up front, with Marcus Berg starting on the bench.
Frankfurt have had a great start to the season with two wins. They want to improve their record with another strong performance against Hamburg.
Hamburg have lost their first two games, but the arrival of Jiracek, Badelj and van der Vaart gives supporters hope that the season will finally start now. The team have had two weeks to improve tactically and integrate van der Vaart into the system.
Expect this to be a close game. Frankfurt have started very well this season, but Hamburg have improved in the last two weeks and are a different team now.
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