Patrick Rakovski will start in goal again, with Raphael Schäfer and Alexander Stephan still out injured.
Javier Pinola returns from suspension and could start at left-back, alongside Marvin Plattenhardt.
Mike Frantz and Alexander Esswein compete for the spot on the left wing. The latter will most likely get his chance this time.
Up front, Tomas Pekhart and Sebastian Polter are the only options for manager Hecking.
Mainz lost their first game after a four game unbeaten streak last weekend. They will be motivated to get back on track with a result in front of their home crowd.
After six games without a win, including five losses, Nürnberg won against Wolfsburg last weekend. They should have regained confidence with this result, but need to continue to work on their defence and chance conversion.
Expect this to be a close game from the outset. Both teams will have to be patient to get their chances.
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