Radoslav Zabavnik and Junior Diaz compete for the spot at left-back.
With Jan Kirchhoff out injured and Julian Baumgartlinger suspended, manager Tuchel has huge problems in defensive midfield. Andreas Ivanschitz could drop back and Yunus Malli could start behind the strikers.
Shawn Parker and Nicolai Müller compete for the spot alongside Adám Szalai up front.
Konstantin Rausch and Christian Pander compete for the spot at left-back.
Christian Schulz and Manuel Schmiedebach compete for the spot alongside Sergio Pinto.
Lars Stindl returns from suspension to start on the right wing, meaning Jan Schlaudraff could switch to the second striker position again.
Mainz have been in good form in the last few weeks and were rewarded with a win at Frankfurt during the week. It remains to be seen how the team will deal without two of their main defensive midfielders, though.
Hannover will have regained confidence during the week with a win against Fürth after having lost the previous two games. The return of Lars Stindl will further improve their balance.
Expect this to be a close game, but how the match pans out will ultimately depend on how well Mainz will deal with their injuries and suspensions.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, articles, graphics, rankings and much more.