Rayo meanwhile kept their amazing run going by securing their fourth consecutive victory with a 2-1 win at Athletic Bilbao last time out.
Paco Jemez's squad will be stretched to the limit as neither of his regular strike duo of Alejandro Dominguez and Leo Baptistao are available, whilst Alejandro Galvez is also suspended.
Their absences should mean a first start since returning to the club for Jordi Figueras and a return to action for Jose Carlos.
On form Rayo should be favourites but Leo is a huge miss for the visitors and in his absence Granada should be able to take something from the game.
Juan Antonio Anquela's men have only won once at home all season though and Rayo have shown themselves to be extremely capable on the road with wins at Betis, Malaga and Valencia already this season.
Scoring goals and creating chances remains Granada's big problem and although Rayo's cavalier style can leave them exposed at times, without the likes of Dani Benitez and Youssef El-Arabi there is no guarantee the hosts will even be able to take those opportunities that do arise.
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