Pepe Mel's Betis missed a pot full of chances as they were held to a 0-0 draw with Real Valladolid.
Cañas was close to a switch to Swansea in January, however Betis pulled the plug on the deal when they realised the majority of the fee would be spent paying off debts and the midfielder will be back in action here.
Two yellow cards in eight minutes last time out mean that Antonio Amaya will be suspended for this match, with Mario favourite to deputise.
Few predicted Espanyol's victory coming in such a comprehensive manner last week, while they have won their previous two home matches 3-2.
A run of six games without a win has seen Betis drop down the table, as dreams of Champions League football have all but evaporated.
Javier Aguirre will be picking up coach of the year award at this rate and there's no reason why his team can't swat Betis aside in a similar manner.
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