Malaga's poor league form continued with a second consecutive home defeat to Real Sociedad last weekend.
Manuel Pellegrini will be able to recall Martin Demichelis and Ignacio Camacho who were both suspended last time out, but Nacho Monreal remains sidelined with a back injury.
The Spanish international's absence means Pellegrini must decide between whether to use Eliseu at left-back or move him forward with Sergio Sanchez retaining his place in defence.
Despite not having the best results, Osasuna's performances at home have been relatively good this season and they will be confident of taking something from a Malaga side that has gone off the boil in recent weeks.
However, the number of key absences the hosts have in forward areas may just prevent them from taking all three points as the visitors will also be boosted defensively by the return of Demichelis and Camacho.
Both meetings between the sides last season ended in draws and with Malaga already having drawn four times on the road this season that outcome looks like the best bet.
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