Malaga's inconsistent league form of late continued as they were poor in losing 1-0 to Getafe last weekend.
However, Manuel Pellegrini's men should be boosted by the return of Nacho Monreal after more than two months out with a back problem, but Jeremy Toulalan has again been ruled out for at least a month with a hamstring injury.
The Spanish international is expected to slot in at left-back with Eliseu moving forward at Francisco Portillo's expense, while Manuel Iturra will replace Toulalan.
Granada remain in the bottom three after a disappointing 0-0 draw with Espanyol last weekend left the home fans calling for manager Juan Antonio Anquela's head.
Anquela has been given at least another week to turn their fortunes around and is likely to reinstate Yacine Brahimi after the Frenchman was only fit enough for a substitute appearance last weekend.
Should Brahimi come back in Anquela must decide whether to relegate Youssef El-Arabi or Odion Ighalo to the bench.
Malaga have won only once in their last six league games, but with the Champions League out of the way now until February they will be looking to re-establish their position as the favourites for another go at the competition next year by virtue of finishing fourth.
They were also spectacular in dismantling Valencia in their last outing at La Rosaleda in La Liga and should have way too much for a Granada side that has showed flashes of quality this season but tends to disappoint.
Moreover, the return of Monreal provides Malaga with much greater impetus as not only does he make his own trademark runs from full-back but he also allows Eliseu to play in more dangerous areas.
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