Atleti suffered their biggest setback this season as they once again failed to live up to expectation in the Madrid derby and lost 2-0 at the Bernabeu.
However, Diego Simeone's men have been invincible at the Vicente Calderon this season, winning all 11 of their games in all competitions, and they should be confident of a return to winning ways against a struggling Depor side.
Simeone will be hopeful that Filipe Luis will be able to overcome the muscular problem that kept him out last weekend as Cata Diaz - who filled in at left-back against Real - will be needed to deputise for the suspended Miranda.
Deportivo suffered the kind of defeat that often afflicts sides that end up being relegated as they fought back from 2-0 down to level at 2-2 against Real Betis before losing out to a wonder goal from Joel Campbell.
Moreover, they have a number of key players missing for the trip to the Calderon as Carlos Marchena and Ze Castro remain out injured, whilst Aythami is suspended.
Their absence means the inexperienced duo of Pablo Insua and Roderick will be paired together at centre-back, whilst Pizzi is also ineligible as he is on loan from Atleti.
Atleti have something to prove once more in front of their own fans after last weekend's disappointment and it is hard to see a Depor side that have been struggling in recent weeks be the first to take any points from the Calderon with their three first-choice centre-backs missing.
Radamel Falcao, in particular, should fancy the prospect of facing that reconfigured backline as he has suffered a relatively fallow period with no goals from open play in his last six matches.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.