Espanyol are still looking for their first win under Javier Aguirre but claimed a morale-boosting 2-2 draw at the Bernabeu on Sunday night thanks to Juan Albin's late equaliser.
Sergio Garcia's return from a four-game suspension also proved a huge boost against the Champions, as he opened the scoring and he is likely to continue in the lone striker's role with Mubarak Wakaso and Simao either side of him.
Goalkeeper Cristian Alvarez is still a doubt so Kiko Casilla will continue in goal.
Deportivo's awful form continued on Monday night as they failed to break down a resilient Valladolid side and now sit bottom of the table having won just once in 15 league games.
Top-scorer Riki is also a doubt with a hamstring injury so Nelson Oliveira could be set for his first start of the season having himself just come back from injury.
Ayoze has also been ruled out for the last game of the year so Evaldo will be handed another rare start at left-back.
This is the definition of a relegation six-pointer, as both sides sit rooted to the bottom of the table on just 12 points from 16 games.
However, it is Espanyol who seem on the rise with three consecutive draws since Aguirre took charge and he will not get a better opportunity to register his first victory than against a Depor side in crisis both on and off the pitch, with the news this week that they could go into administration by the end of the year.
Garcia's return also gives the Catalans a more potent threat than they have had all season with the likes of Christian Stuani and Samuele Longo and he could be the key man as they look for the perfect Christmas present in only their second home win of the season.
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