Sevilla secured a morale boosting 5-0 win away at Mallorca in the Copa del Rey in midweek with Alvaro Negredo continuing his fine form on his return from injury with two goals.
The Spanish international will therefore take his place up front after coming on to score a last minute equaliser against Espanyol last weekend and Gary Medel also returns from suspension.
Jose Antonio Reyes has been cleared to play too as his red card at the Cornella El Prat last weekend has been rightfully rescinded and Geoffrey Kondogbia is expected to keep his place in the absence of Piotr Trochowski and Hedwiges Maduro.
Malaga got their league campaign back on track with only their second win in six league games, as they thrashed Granada 4-0 at La Rosaleda last weekend.
Manuel Pellegrini may make one change from the side that started last time out though as Manuel Iturra could be recalled ahead of Francisco Portillo to offer greater protection to the back four.
Nacho Monreal's return from injury was also key in Los Boquerones return to form and his partnership with Eliseu could be key if Pellegrini's men are to get their first away win in La Liga since the 1st of September.
Another Andalusian derby should ensure a fiery atmosphere at the Sanchez Pizjuan where, after an extremely strong start to the campaign, Sevilla have stumbled of late, in particular in games against Levante and Valladolid.
However, the return of Negredo makes such a huge difference to Michel's men and his presence should ensure Los Nervionenses are more than a match for their high-flying visitors.
Malaga's style should, though, suit playing a side like Sevilla's who will come at them as they can then break with the pace of Eliseu and Joaquin out wide and Saviola through the middle.
Both games between the two were won 2-1 by the home side last year, reflecting how evenly matched they are and expect another close encounter with plenty of passion in the stands and good quality football on the pitch.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.