Atleti slipped nine points behind Barcelona as the Catalans came from behind to beat Diego Simeone's men 4-1 last weekend and strengthen their hold on the title race.
However, los Rojiblancos were boosted by Real Madrid's slip-up at home to Espanyol which means they will definitely finish the year in second place, no matter what happens this weekend.
Filipe Luis limped off at half-time at the Camp Nou and will miss out with the thigh injury that has bothered him in recent weeks. Cata Diaz will most likely fill in at left-back, whilst Adrian could also replace Koke should Simeone look to go for a more attacking option.
Celta's inability to take chances cost them again on Monday night as Jorge Molina's last goal gave Betis all three points at Balaidos to leave the Galicians just two points above the drop zone.
Monday's game also cost Paco Herrera on the injury front as Roberto Lago has been ruled out of the trip to the Calderon with a muscular problem so Carlos Bellvis will come in at left-back.
Cristian Bustos is also expected to come into midfield with Michael Krohn-Dehli moving back to the left side of the attacking three as Herrera looks for a more defensively secure option ahead of the daunting trip to the Europa League champions.
Atleti have been phenomenal at home this season with 13 wins out 13 in all competitions so far and that 100% record is unlikely to be upset before the end of the year against a Celta side that has lost seven of their eight away league games on their return to the top-flight.
Radamel Falcao has also returned to the stunning form he displayed earlier in the season with six goals in his last two outings and is the man most likely to do the damage again as Atleti look to open up a seven-point gap on rivals Real Madrid ahead of their tricky trip to Malaga on Saturday night.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.