Sevilla's problems continued as they slipped to within just four points of the relegation zone with a 2-1 defeat at Real Sociedad before the break.
Coke is suspended after being sent-off in that match so Cicinho should return at right-back, whilst injuries to Jose Campaña and Hedwiges Maduro are likely to mean Geoffrey Kondogbia will keep his place in central midfield.
With the club also in financial difficulty Alvaro Negredo has been linked with a big-money move this month, but President Jose Maria Del Nido has insisted the Spanish international will stay and indeed Michel could even hand a debut to new signing Miroslav Stefanovic after he completed his transfer from Vojvodina.
Osasuna meanwhile slipped back into the relegation zone with defeat at home to Granada last time out.
Alejandro Arribas is suspended for the trip to the Sanchez Pizjuan so Ruben Gonzales is likely to partner Miguel Flaño in central defence.
Anthony Annan is also unavailable as he has joined the Ghanian squad for the Africa Cup of Nations, but Emiliano Armenteros does return from a ban and is expected to take Roland Lamah's place on the left side of midfield.
Sevilla's form before Christmas was awful with four defeats and a draw from five games, but the break has allowed them to get some of their injured bodies back fit and the return of Ivan Rakitic in particular could be significant.
Osasuna, meanwhile, are still lacking a goal threat since the departure of Raul Garcia in the summer and should they not address that problem this month it could result in a return to the Segunda for the first time since 2000.
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