Zaragoza continued their strong away form just before the break with a comfortable 2-0 success at Athletic Bilbao, but it is at home that Manolo Jimenez's men have struggled with five defeats in eight games.
Jimenez is expected to name the same side that won at San Mames despite the return of Adam Pinter and Carlos Aranda.
Betis, meanwhile, failed to capitalise on their momentum as they went down 2-1 at home to Mallorca three weeks ago and are now three points off Malaga in the chase for the fourth Champions League place.
With Juan Carlos ruled out for a couple of weeks, Ruben Castro may again drop into a deeper role to allow Jorge Molina to lead the line, whilst there could also be a return for Paulao after being frozen out by the good form of Mario in recent weeks.
Like so many of the sides in La Liga this season, the fact both these teams have done better on the road indicates that both are happier to soak up pressure and counter-attack, than try to make the game themselves.
That would therefore suit Betis this time out, but some of Los Verdiblancos away results have also contained a good deal of luck with other sides wasting opportunities, something that Zaragoza are less likely to do with the Helder Postiga up front.
The hosts will also be wary not to over-commit and allow the likes of Joel Campbell space to break into, so the result could be a cagey game with the spoils being shared.
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