Bizzarri will replace goalkeeper Marchetti, who is injured and will not travel to Bologna.
Klose's availability is still uncertain, and Kozak and Floccari both proved to be reliable options in case the German striker is unable to be passed fit.
Cavanda will play as right-back as Konko is injured as well.
Bologna won their last match against Atalanta and avoided falling to last placed in the table, but they still need more points to keep out of the danger zone. Two consecutive home matches could do the job, but Lazio are in very good form.
Three victories and one draw in their last four league matches, plus the big win over Maribor, mean Lazio will be favourites in this match. Playing on Monday will give the Biancocelesti one more day to rest and prepare for the match properly.
Petkovic's main concern at the start of the season was Klose's physical reliability as his age suggests he can't play two matches every week. However, his substitutes Kozak and Floccari have proven to be in good form and may replace the German striker as Lazio's finishers.
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