Star striker Matias Suarez is out after undergoing knee surgery which is a major blow for the Belgian outfit, with De Sutter and Mbokani set to lead the line.
Former Liverpool-man Milan Jovanovic is suspended and will miss the trip to San Siro.
Anderlecht will look to the likes of Biglia in the midfield and the experience of centre-backs Wasilewski and Deschacht at the back to get a result.
AC Milan will be desperate to avoid three consecutive home defeats when Anderlecht visit San Siro but their start to the season has left little to assure the fans of another successful season ahead.
Anderlecht will perhaps make the trip to Italy in a more confident mood due to Allegri's side's indifferent form, though the Belgians have slumped to three consecutive league draws after a good start to the season.
Despite lacking firepower Milan should have enough to beat Anderlecht at home but this may not be plain sailing for the hosts as the Belgian's will look to defend resolutely from the outset.
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