Jose Mourinho has overseen a distinctly indifferent start to his side's La Liga campaign, with Real Madrid having won only 1 of their opening 4 fixtures. They are already 8 points behind Barcelona and will need to turn things round soon.
They have no injury worries for the visit of Man City, and could field the same XI that lost to Sevilla at the weekend, though Karim Benzema is likely to come in up front in place of Gonzalo Higuain.
Angel Di Maria had a poor game, so Modric, Kaka and Callejon will all be pushing for a starting place
Roberto Mancini has no new injury concerns ahead of his side's trip to the Bernabeu, and look set to recall Sergio Aguero the the starting XI. The Argentine returned to training on Friday and there was talk that he might have been fit to play at Stoke. He did not feature in that game, though, and will be better off for this game as a result.
Gareth Barry made his return to first team action from the bench at the Brittania, and he is in competition with goalscoring debutant Javi Garcia for the central midfield spot alongside Yaya Toure.
Richards is still out and Zabaleta has a knock which could keep him out of the side, meaning Maicon could start at right-back again.
At left-back, Clichy played the whole game at Stoke, and it is anyone's guess whether Mancini will stick with the Frenchman or bring in Kolarov, who will be fresh having not featured at the Brittania.
With their domestic campaign having started so badly, Real Madrid would have been hoping for a little reprieve in the Champions League, but they certainly won't get any here, with Premier League champions Manchester City coming to play. Real will be favourites given their European pedigree, but City will give them a run for their money.
City come to the Bernabeu off the back of a disappointing 1-1 draw at Stoke at the weekend, but a few of their first team players were rested and will be fresh to start here. They may not see as much of the ball as they are used to in league matches, but they will create chances and look to expose a shaky Real backline.
Billed as a battle of the tacticians, Jose Mourinho takes on Roberto Mancini, and it will be extremely interesting to see how both sides' tactics differ to those that they usually play. Mourinho is always likely to spring a surprise, and particularly given recent results, there could be some unexpected players on the pitch come kick off.
This should be a great game between two teams that play fantastic attacking football, and will be a great watch, though the Spanish champions' experience could just be the difference.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.