Vucinic, Lichtsteiner and Asamoah were all rested from kick off at the weekend and will return, while Vidal was an unused substitute in Genova and will be fresh for the trip to London.
Elsewhere new signings Lucio, Isla and Bendtner may all have to watch on from the bench at the start.
De Ceglie, Caceres and Matri will drop to the bench, with Asamoah and Lichtsteiner the wing-backs in a 3-5-2 formation.
In what is undoubtedly one of the most mouth-watering opening Champions League encounters holders Chelsea host Serie A champions Juventus, who haven't lost in their last 42 league games.
For that reason Chelsea, despite their home advantage, may not be favourites on Wednesday and they will need to try and counter against the visitors extra man in midfield whilst also allowing Hazard the freedom to attack.
The hosts will have a tough task cracking Juve's defence but may have their biggest problems in the midfield, where the Italian's have been so dominant domestically.
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