Jeremy Toulalan and Nacho Monreal are nearing fitness but this game is likely to come too soon for the duo.
Eliseu will therefore continue to play at left-back, while Duda may replace Iturra in midfield and Santa Cruz will hope to start ahead of Saviola up front after a surprise defeat at the weekend.
Portillo could line up on the right, with Joaquin switching to the left and Isco deployed behind the central striker.
Malaga have started their debut season in the Champions League superbly, but their impressive campaign to date hit a snag against Vallecano, while Milan's confidence will be at an all-time high in a disappointing season after they crushed Chievo at the weekend.
The Spaniard's are yet to concede a goal in Europe but the hosts' forwards finally seem to be beginning to click, so they would do well to come away from San Siro with another clean sheet.
The visitors may well drop their first points in the competition, happy to take a draw from this game to all but assure their progression, so Milan will look to take the game to the away side in pursuit of all three points.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.