Xabi Alonso returns to the starting XI after missing the win over Zaragoza due to a domestic suspension. He will be partnered in front of the back four by either Luka Modric or Michael Essien, as Sami Khedira is still out injured.
Fabio Coentrao and Marcelo remain absent, so Alvaro Arbeloa will play at left-back.
Varane and Albiol are in contention to play at centre-back, with Ramos set to play on the right once again.
Sebastien Kehl could play despite being forced off in the first half of the weekend's goalless draw with Stuttgart through injury.
His midfield partner is likely to be Ilkay Gundogan, although Sven Bender is nearing a return from injury and will be pushing for a starting spot.
Duksch and Blaszczykowski remain absent.
Few would have doubted Borussia Dortmund's credentials ahead of this season's Champions League campaign, but even fewer would have predicted that they'd be top of this group after three rounds of matches. The only time they have dropped points remains the draw at Manchester City, which was largely due to a harsh penalty decision in the dying minutes.
Real Madrid dropped points when these sides met a fortnight ago, and will need to be wary of the threat that Dortmund pose going forwards. However, since that loss, Madrid have won three games in a row, scoring 13 goals, and will certainly have their confidence back.
The Spanish side have only dropped points once at home all season - the 1-1 draw with Valencia at the start of the season - and many will expect them to win again here. Dortmund are a fantastic side, and they proved that in getting one over their opponents last time out, but a win at the Bernabeu might just be too much of an ask.
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