Strikers Matias Suarez and Cyriac remain sidelined for the Belgian outfit, with Mbokani set to lead the line over De Sutter.
Anderlecht have been unchanged in their last 3 matches and having won them all, including a victory over Zenit in their last Champions League game, rotations are unlikely.
In that case Safari is likely to keep his place over Deschacht at left-back, with Cheikhou Kouyate playing at centre-half ahead of Marcin Wasilewski and American Sacha Kljestan in the double pivot with captain Lucas Biglia.
Allegri will have been happy to see his side come from two down against Napoli at the weekend and may stick with the same XI, with Boateng dropping in behind the two strikers this time.
Pato, Robinho and Pazzini are all available and strong options in attack, but the in form El Shaarawy is likely to be partnered by Bojan once again.
The defence should remain unchanged, with De Sciglio keeping his place on the right in the absence of Ignazio Abate.
This is a very important match in group C, with just one point separating the sides looking to progress alongside the already qualified Malaga.
Milan know that a win would knock the Belgian's out of the competition and could also see them qualify if Zenit failed to win against the aforementioned Spanish outfit.
The hosts will be keen to take the driving seat with a win themselves, however, and would go into the final game against what would probably be a weakened Malaga side only needing a draw if they were to get the three points here.
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