Spurs manager Andre Villas-Boas has explained that he is looking to go all the way in this season's Europa League, so his side will be taking the competition more seriously than they have done in recent years. His team selection will reflect that, with only a few changes expected from the side that beat Reading at the weekend.
French no. 1 Hugo Lloris is expected to make his debut between the posts, while Clint Dempsey, having come on against Reading, should get his first start. However, as of yet it is unclear who the American will come in for, as he is versatile enough to play in any of the 4 attacking positions.
AVB confirmed that Emmanuel Adebayor is injured and will not feature. That may explain why he did not feature at the weekend, but he will be frustrated at not finding a way straight back into the first XI at WHL.
Assou-Ekotto is expected to be out for up to 4 weeks with a knee injury.
Senad Lulic has recovered from the knock he picked up while on international duty with Bosina, though he is still only likely to make the bench for Lazio.
Vladimir Petkovic could stick with the same team that won so convincingly at Chievo at the weekend.
Hernanes will be the main threat for the Italians once again, and Spurs will need to stem his creativity in order to stand a chance.
Tottenham Hotspur picked up their first win of the season, and first under Andre Villas-Boas, with a 3-1 win at Reading at the weekend. Although the scoreline in no way flattered the Londoners, they were certainly aided by an extremely poor Reading performance.
Lazio will not make things quite so easy this time around, the Italians having started their season with 5 wins from 5 competitive games in Serie A and the Europa League qualifiers. Hernanes has been in fantastic form, having averaged a WhoScored rating of 8.74 in league games, scoring 3 goals and picking up an assist. He will be given the freedom to roam where he pleases and try and find space in which to work his magic.
Europa League group ties can often turn out to be pretty drab affairs, but with 2 quality teams on show, there should be some good football played, with goals to boot. Spurs' home advantage will help, but with Lazio's start to the season they should prove too good to beat.
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