Gareth Bale and Michael Dawson both limped off during the win at Fulham last weekend with hamstring injuries and will miss out here as a result.
Scott Parker came through 90 minutes unscathed in a reserve team friendly this week as he stepped up his recovery from an achilles injury, but this game will be too soon for him.
Emmanuel Adebayor will probably start up front after having missed the last 3 league games through suspension, with Andre Villas-Boas eager for the Togolese striker to build up his match fitness once again.
Andros Townsend could start on the left, while Tom Carroll will likely play a part, though probably from the bench.
Panathinaikos have no injury worries ahead of the trip to White Hart Lane, where only victory is enough to send them through to the next round.
Jean-Alain Boumsong and Quincy Owusu-Abeyie are two players that have played in England before and could line up for the Greek side here.
José Toché leads the goalscoring charts for Panathinaikos in the Europa League this season, and he will play as the lone striker once again.
Tottenham stand a good chance of making the knockout stages of the Europa League this season, though they must first overcome a Panathinaikos side that are 3rd in the group and could sneak through with a win here.
It seems that Spurs' players have found it difficult to motivate themselves in the Europa League this season, with plenty of lacklustre displays and low scoring draws. They will not want to bow out at this early stage in the competition, though, and will be sure to be fired up for this game.
The Greek side's win over Maribor last time out has given them a fighting chance of making it through the group stages, but away from home in Europe they have lost both of their games 3-0. In fact, they have only won 3 of their last 10 competitive away games and so victory seems extremely unlikely. Spurs should do a professional job and get themselves through to the next round.
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