Injury to Neven Subotic has kept the Serbian out in the New Year but he was fit enough to make the bench against HSV and could return in place of Felipe Santana.
Both Marcel Schmelzer and Kevin Grosskreutz missed out at the weekend and Klopp will be hoping the former is fit in midweek having had to field Sven Bender out of position at left-back.
Ilkay Gundogan misses out with a thigh problem so Kehl, Bender and Sahin compete for the two spots in midfield.
Shakhtar have been on a winter break since the start of December in the league, playing as many friendlies as possible in preparation for this game, though the lack of competitive action of late may affect them and the loss of Willian in that time was a huge blow.
Dortmund followed up a much needed win over Leverkusen with a shock defeat to Hamburg and the manner of the 4-1 loss may well have been a blow to the morale of Jurgen Klopp's side.
The German outfit have been more impressive in Europe than they have domestically, however, and should raise their game again to ensure that this is one of the most exciting ties of the round.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, articles, graphics, rankings and much more.