Manchester United have worries over the fitness of Phil Jones and Jonny Evans, both of whom were forced off injured during the win over Everton on Sunday.
However, both have trained - as has Ashley Young - and all three should be available for selection.
Nonetheless, Rio Ferdinand was rested for that game and is likely to partner Nemanja Vidic at the heart of defence.
Paul Scholes has been left out of the squad for the trip to Madrid, and Sir Alex Ferguson could opt to play Phil Jones in defensive midfield along with Carrick and Cleverley as he has done a few times this season, including against Spurs and Everton recently.
Undoubtedly the pick of the ties in the Champions League last 16 sees two giants of world football, Real Madrid and Manchester United, face off, with Cristiano Ronaldo up against his old side for the first time since his record move to the Bernabeu.
All the attention will be on Ronaldo in the build up to this game. He scored a hat trick in the win over Sevilla at the weekend and will be the main threat for the Spaniards, but Sir Alex Ferguson knows him better than most and may have a gameplan to deal with him.
Utd are completely dominating the Premier League, 12 points clear at the top and all but certain to win the title. They will be fully focussed on getting past Real, who are somewhat out of sorts at the moment, 3rd in La Liga and 16 points behind Barcelona.
These sides produced an unbelievable tie when they last met back in 2003. Real won the first leg 3-1 in Spain, before the other Ronaldo scored a hat-trick at Old Trafford in a 4-3 win for Utd that was enough to put the Whites through. With all the attacking talent these two have we could be in for another goal-filled tie, with Real taking a narrow lead to England for the return leg.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.