Brendan Rodgers' side face this tough game in Russia just 3 days after a 2-0 home defeat to West Brom and only 3 days before they face Swansea on Sunday.
He may therefore rest the likes of Steven Gerrard, but Luis Suarez is probably going to be needed given that Daniel Sturridge is cup-tied.
Coutinho is also ineligible, while Kelly and Flanagan remain absent through injury.
Liverpool face an uphill task if they are to progress in the Europa League, going to St Petersburg for this first leg, where Zenit have never lost to an English side.
Zenit haven't played a competitive game since early December, so it will be interesting to see whether they return to action fresh and raring to go, or rusty and out of practice.
It will probably be in Liverpool's interests to start quickly and try and catch Zenit unawares early on in the tie. Even a solitary away goal would give them a huge advantage in the tie, but Zenit might just have too much attacking talent for Liverpool to handle.
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