Jorge Jesus must decide whether to go with one or two up front in Leverkusen, with Lima, Rodrigo and Cardozo all fighting for places in the starting XI.
Jardel should start ahead of the experienced Luisao, with Nemanja Matic acting as the protection to the back four.
Ola John could get the nod over Gaitan on the left, with Salvio lining up on the opposite flank.
This should be a really entertaining game with the pace from the wings of both sides likely to be an important factor. Benfica are unbeaten in the league, while Leverkusen are flying high in third.
Kiessling is in great form for the hosts and with support from the likes of Schurrle, Castro and Bender, manager Sami Hyypia has a very strong team nowadays. Benfica's attacking threat throughout the squad could see the likes of Cardozo, Gaitan and Aimar only make the bench.
It's hard to pick a winner in what will be one of the most intriguing encounters of the round but Leverkusen's home form, having only lost 1 all season as hosts (last time out against Dortmund), could see them prevail.
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