Rubin are likely to mirror Atleti's 4-2-3-1 lineup for the trip to the Vicente Calderon.
After 2 months without a competitive game, there could be some surprises in the Rubin team selection.
With 4 goals in the group stages, Salomon Rondon is all but certain to lead the line up front.
Undoubtedly Atletico Madrid's priority this season will be to maintain their lofty position in La Liga, but they always take Europe's second competition completely seriously and will also be looking to retain their trophy.
They made it through the group stages relatively easily given that Diego Simeone fielded second string players for the most part, but the knockout phase could see the return of Falcao and co. to the fold.
Rubin Kazan haven't played a competitive game since early December and could start slowly as a result. Their form before the winter break was dodgy - no wins in their last 4 games - and while Atletico have wobbled away from home, they have won all 19 of their home games in all competitions this season, conceding only once in their last 12. Expect them to continue that run in commanding fashion.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, blogs, graphics, rankings and much more.