Yoann Gourcuff has missed the last couple of games with a groin injury and isn't expected to make it back just yet.
Jimmy Briand is lacking match fitness and also won't feature.
Lyon bounced back from the defeat at White Hart Lane last week with a resounding 4-0 win at Bordeaux on Sunday, with Clément Grenier scoring twice, so he could push Steed Malbranque, who was rested at the weekend, for the spot behind the lone striker.
Brad Friedel will continue in goal for Tottenham, as Andre Villas-Boas continues with his policy of goalkeeper rotation in spite of Hugo Lloris' connections with Lyon.
Tom Huddlestone is a doubt after missing the first leg of this tie with a knee injury, but he is unlikely to be involved anyway.
AVB will want to win, but will also have an eye on Spurs' Monday game at West Ham, so his centre back pairing could give an indication of who he is going to field in the next match, with 2 able to rest here.
An outstanding long range strike from youngster Samuel Umtiti was flanked either side by two fine Gareth Bale free kicks in the first leg last week, with neither side creating many clear cut chances.
Bale's late winner has made a big difference to this tie, as now Lyon have to come out to attack Tottenham, which will play right into the visitors' hands. They thrive when space is left for them to counter attack into, and they could catch Lyon on the break with a vital away goal.
Both sides possess the attacking flair to score goals here, and the home side will need to go in search of one from the off. They scored 4 against Bordeaux at the weekend, but Spurs have won their last 3 games and should be defensively sound enough to nick a draw and progress.
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