- With Spain stalwarts Xavi, Xabi Alonso and Iker Casillas all missing out through injury, Iniesta and Fabregas should join Busquets in the midfield three, while Victor Valdes will get a rare chance in goal.
- Chelsea's Cesar Azpilicueta could make his international debut here, having impressed and held down a first team place since his move to London.
- Without Torres or Soldado in the squad, David Villa should start, though many will have been disappointed with Michu missing out.
- Southampton playmaker Gaston Ramirez misses out due to the injury that forced him off at half time against Wigan at the weekend.
- Diego Lugano could be involved having played the last couple of games for Malaga since his loan move in January.
- Forlan, Cavani and Suarez will lead the line together in what is an attack line that would strike fear into any defence.
- The world and European champions face Uruguay in Doha for this friendly, which pits 2 of the 4 semi-finalists at the last World Cup against one another.
- Spain have continued to dominate international football since then and even without someone like Xavi they should be far too strong for their opponents here.
- Uruguay, since coming 4th in South Africa, have somewhat fallen from their pedestal, dropping to 16th in the world rankings. They are also 5th out of 9 in the South American qualifying group for the next World Cup, behind the likes of Venezuela and Ecuador, and are facing the distinct possibility of failing to make it to Brazil 2014. They will be taking this match very seriously as they look to get things back on track, but Spain will control proceedings and should win comfortably.