Joël Veltman, Daley Blind and Siem de Jong all returned to group training this week but it is expected that all three will not feature against PEC Zwolle.
Blind has the strongest chance to make the matchday squad but Nicolai Boilesen should continue at left-back.
Stefano Denswil is expected to continue in central defence alongside Niklas Moisander.
Thulani Serero, who sat out of international duty with complaints of a groin injury, is medically cleared. If he doesn't make the starting line-up – he could possibly be saved for the upcoming game against Barcelona – then Lerin Duarte, who joined from Heracles on deadline day, will make his debut.
PEC Zwolle will be without Youness Mokhtar who left for FC Twente, while first choice goalkeeper Diederik Boer is out injured. Furdjel Narsingh and Ronnie Reniers are also sidelined.
Jesper Drost, who has quietly impressed this season in midfield, is also ruled out of the trip to Amsterdam with a groin injury.
Ajax will look to end PEC Zwolle's unbeaten start to the Eredivisie season when the two teams meet at the Amsterdam ArenA on Saturday.
Frank de Boer's champions have endured an unconvincing start to the campaign, winning two, drawing twice and losing once in their opening five games.
Zwolle, by contrast, won their first four games and top the table, with their 1-1 draw with Utrecht prior to the international break marking the first time this term that Ron Jans' men have dropped points.
Jans, who takes much of the credit for PEC's ascent – returning to the Dutch top flight after a disappointing spell at Standard Liège in Belgium – believes his side can upset the Amsterdammers in their own back garden.
However, Ajax will be confident of inflicting Zwolle's first league defeat of 2013-14, having done the double over them last season, scoring seven goals in the process.
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