Zakaria Bakkali, who missed PSV's last four games, including both Champions League ties against AC Milan with a groin injury, is expected to make his return this weekend.
However, there's also the possibility of Phillip Cocu starting him on the bench, with Park Ji-Sung preferred instead.
The game against FC Twente has come too early for Karim Rekik, who is struggling with an ankle injury, so Jorrit Hendrix is set to continue alongside Jeffrey Bruma.
Georginio Wijnaldum, who pulled out of the Netherlands' recent internationals, is expected to take his place in midfield.
Second meets third when PSV Eindhoven travel to Twente. PSV know that they will go top with a win coupled with a PEC Zwolle defeat. The abundance of talent on either side, in recent seasons, has ensured whenever FC Twente and PSV meet it goes down as a game worth watching. It will be no different this Saturday.
Back-to-back draws in the league, including a dull goalless affair at home to Cambuur last time out – which just so happened to fall on the date of their founding 100 years ago – have grounded Phillip Cocu's swashbuckling PSV. Michel Jansen, on the other hand, can be content with the development of his Twente side. The focus this season is on rebuilding.
PSV have yet to taste defeat in 2013-14 but they face a stern test at De Grolsch Veste, where they have not won in the league since 2005.
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