Andy Carroll is ruled out with the heel injury that forced him to miss the 2-0 win over Cardiff City, with the problem expected to sideline him until next month.
George McCartney is also injured, while Razvan Rat and Stewart Downing will have to wait to make their West Ham debuts.
Sam Allardyce is set to name an unchanged XI from the side that defeated Cardiff last week.
Losing Steven Taylor will be a huge blow to manager Alan Pardew as Newcastle look to get their domestic campaign up and running following the 4-0 thumping at the hands of Manchester City.
Yohan Cabaye continues to be linked with a move away from St. James' Park and is set to play no part in the encounter, while Vurnon Anita is expected to replace Jonás Gutiérrez in the starting XI due to injury.
Sam Allardyce will likely name an unchanged starting XI from last weekend's win over Cardiff City.
Andy Carroll is injured, while Razvan Rat and Stewart Downing - both of whom started from the bench during the victory at Upton Park - are unlikely to start here.
While Pardew may have a mounting injury list, and West Ham hitting the ground running, a score draw is the likely outcome.
WhoScored.com provides you with unparalleled football statistics, as
well as detailed football previews and football rankings from competitions all over the
world. Our live, in-depth football statistics from the Premier League,
supplies unique and original insights for football fans, sports
betting punters, journalists, football managers and players. We also have football tables,
live scores, top performing players as calculated with our unique WhoScored.com
ratings, articles, graphics, rankings and much more.