The likes of Walcott, Wilshere, Özil and Ramsey all remain sidelined through injury.
Alex Oxlade-Chamberlain has recovered from a minor calf problem that saw him withdrawn in the second half at Spurs.
The back four will remain unchanged, while Wenger will be weighing up whether to field the defensive minded Flamini, sacrificing either Podolski or Rosicky.
Chelsea will have been buoyed by their progress in the Champions League but must bounce back from the defeat at Villa last weekend against a fellow title rival.
Victory for Arsenal would see the Gunners move to within one point of the Blues with a game in hand, while a home win would mean the gap becomes difficult to bridge for Wenger's men.
This may well be a cagey affair due to the importance of the game, particularly in the opening exchanges, with Mourinho insisting on a solid defence before anything else in such crucial matches. The backlines could win out to ensure a draw that will please both City and Liverpool more than the two teams involved.
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